Biochemical Alterations of Stored Erythrocyte Membranes

Coagulation Clinical Trial

Official title:

Biochemical Alterations of Stored Erythrocyte Membranes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02639780
• Other study ID #: 1043/2015
• Status: Completed
• Start date: December 2015
• Est. completion date: December 2021

Study information

• Verified date: January 2022
• Source: Medical University of Vienna
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators will define procoagulant properties of packed red blood cells and investigate whether packed red blood cells from certain donor populations are prone to induce procoagulant states.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: December 2021
• Est. primary completion date: November 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• group 1: healthy female volunteers 18-35 y.o.
• group 2: healthy male volunteers 18-35 y.o.
• group 3: healthy female volunteers 36-60 y.o.
• group 4: healthy male volunteers 36-60 y.o.
• group 5: female volunteers 36-60 y.o., BMI 26-45
• group 6: male volunteers 36-60 y.o., BMI 26-45

Exclusion Criteria:

• age below 18 years
• age above 60 years

Related Conditions & MeSH terms

• Coagulation

Intervention

Other:
• protein expression pattern of packed red blood cells
the proteome of packed red blood cells will be assessed at predefined time points

Locations

Country	Name	City	State
Austria	Medical University of Vienna	Vienna

Sponsors (3)

Lead Sponsor	Collaborator
Medical University of Vienna	European Society of Anaesthesiology, Medical Scientific Fund of the Mayor of Vienna

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	protein expression pattern		week 0
Primary	protein expression pattern		week 2
Primary	protein expression pattern		week 4
Primary	protein expression pattern		week 6