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Clinical Trial Summary

The aim of this study is to determine the efficacy in seizure reduction when comparing orodispersable clonazepam versus usual treatment (i.e. medication load, intravenous high- dose benzodiazepines) of seizure clusters in a third level center of care in Mexico city.


Clinical Trial Description

This is an open label, randomized, prospective clinical trial, with a 1:1:1 aleatorization of a single third level specialized neurological center. Primary objective: To evaluate the clinical impact of the use of buccal midazolam as a treatment of seizure clusters in comparison with orodispersable clonazepam vs usual care. Secondary objective: To identify patients that present seizure clusters and risk factors associated with the diagnosis. To evaluate the quality of life after drug administration, to evaluate the adverse events associated with the medications. To establish seizure recurrence and mortality in 6 months' follow up. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06056349
Study type Interventional
Source El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Contact Elma M Paredes-Aragón, MD
Phone 5556063822
Email elma.paredes@innn.edu.mx
Status Recruiting
Phase N/A
Start date May 1, 2023
Completion date December 31, 2024