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Allogeneic CARCIK-CD19 in Adults/Pediatric B-cell NHL or Chronic Lymphocytic Leukemia

CLL Clinical Trial

Official title:
Phase I/II Trial to Determine the in Vivo Engraftment, Safety and Clinical Activity of Allogeneic CIK Cells Transduced With a Transposon CD19-chimeric Antigen Receptor (CARCIK-CD19) Gene in Adult and Pediatric Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

Clinical Trial Summary

This is a single arm, open-label, multi-center, phase I/II study to determine the engraftment, safety and clinical activity of allogeneic CARCIK-CD19 cells in adult and pediatric patients with relapsed/refractory mature B-cell neoplasia expected to express CD19 i.e. B-cell NHL and CLL. CARCIK-CD19 will be produced from the peripheral blood of an at least haploidentical familial donor.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05869279
Study type Interventional
Source Fondazione Matilde Tettamanti Menotti De Marchi Onlus
Contact Andrea Biondi, MD
Phone +39039233
Email segreteriadirezionecp@fondazionembbm.it
Status Not yet recruiting
Phase Phase 1/Phase 2
Start date September 1, 2023
Completion date September 1, 2027
View Details
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