Does the Volume of the Embryo Culture Medium During Embryo Transfer Affects the IVF Outcomes?

Clinical Pregnancy Rate Clinical Trial

Official title: Low Versus High Volume of Culture Medium During Embryo Transfer: a Randomized Clinical Trial.

Status Completed

Clinical Trial Summary

The aim of this study was to evaluate if higher volume (40-45μl VS 20-25 μl) of media used for embryo transfer affects the clinical outcomes in fresh IVF cycles.Patients who fulfilled the inclusion criteria and agreed to participate in the study, were randomized, on the day of the embryo transfer, into group A: low volume (20-25 μL) and group B: high volume (40-45 μL)

Clinical Trial Description

The volume of culture medium used for embryo transfer is a variable that has been speculated to affect the IVF outcome. It is known that ultra high volume (>100 μl) of medium during embryo transfer may result in embryo expulsion out of the uterus or ectopic pregnancy. Similarly, some authors advocate that ultra low volume of transferring medium (<10 μl) may negatively affect pregnancy and implantation rates.

However small differences in the volume of the culture medium may favor the outcome of the embryo transfer. The aim of this study was to evaluate if the use higher volume (40-45μl VS 20-25 μl) of media used for embryo transfer affects the clinical outcomes in fresh IVF cycles. ;

Related Conditions & MeSH terms

• Clinical Pregnancy Rate

• NCT number: NCT03350646
• Study type: Interventional
• Source: Aretaieion University Hospital
• Status: Completed
• Phase: N/A
• Start date: November 2014
• Completion date: June 2017