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Cleft Lip clinical trials

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NCT ID: NCT06284434 Active, not recruiting - Clinical trials for Cleft Lip and Palate

Liposomal Bupivacaine Use in Alveolar Bone Graft Patients

Start date: April 24, 2024
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial is to learn if a pain medication called liposomal bupivacaine (brand name EXPAREL®) with epinephrine will provide better pain control, increased activity, and reduced use of opioids compared with the standard treatment for patients age 6 years and older with cleft lip and palate who have had an alveolar bone graft surgery. Investigators will look at: - pain scores at hip and jaw sites - opioid use in amount and frequency - scores on activity questionnaires Researchers will compare the results of these items with those of patients who had the standard treatment of bupivacaine with epinephrine.

NCT ID: NCT06067854 Active, not recruiting - Clinical trials for Perioperative Analgesia in Neonates

Perioperative Analgesia in Neonates Who Underwent Primary Cleft Lip Repair Surgery

Start date: January 1, 2022
Phase:
Study type: Observational

In retrospective data search the investigators will identified the cumulative consumption of opioid analgesics during surgery and 24 hours after surgery in neonate with cleft lips who underwent primary cleft lip repair surgery.

NCT ID: NCT05971914 Active, not recruiting - Clinical trials for Cleft Lip and Palate

Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft

Start date: October 12, 2021
Phase: N/A
Study type: Interventional

The present study aims at clinical and radiographic evaluation of the safety and efficacy of Bonmaker ATB powder combined with a novel split thickness papilla curtain flap in the treatment of alveolar cleft defects.

NCT ID: NCT02454998 Active, not recruiting - Cleft Lip Clinical Trials

Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment

Start date: February 2011
Phase: N/A
Study type: Interventional

Alveolar bone grafting (ABG) is an essential part of the surgical management of cleft lip and palate patients. This procedure could obliterate oronasal fistula, stabilize dental arch, offer bone matrix for adjacent teeth eruption. Moreover, by obliterating oronasal fistula, we stop the chronic irritation of nasal mucosa by oral content. Hence, the symptoms of rhinorrhea or nasal obstruction could be improved. This dental arch defect could predispose further dental arch medial collapse. Without alveolar bone grafting the dental arch is not stable, dental movement during orthodontic treatment is limited and dental arch expansion is not possible. Previous to operation, the patient suffered from dental crowding and dental inclination toward to the cleft. This produces a difficult dental hygiene and predispose to dental caries and gingivitis. Pre-operative orthodontics treatment is advised in many centers. By aligned the teeth previous to surgery, with a better dental hygiene, we purpose that the infection rate will be reduced and success rate will be better. The Purpose of this study is to determine whether pre-operative orthopedic treatment will affect secondary alveolar bone grafting outcome and to assess the nasal change after alveolar bone graft.

NCT ID: NCT00975208 Active, not recruiting - Cleft Lip Clinical Trials

Osteogenesis and Dental Eruption Through Electrical Stimuli

Start date: January 2006
Phase: N/A
Study type: Observational

The closure of the alveolar cleft as part of cleft lip and palate deformities is a procedure that, to this date, still demands great efforts from plastic surgeons. The feasibility of periosteoplasty for reconstruction of the alveolar arcade as well as the use of electrical stimulation in order to increase osteoneogenesis have been proven in the past. The present study attempts to combine both procedures that have only been reported separately worldwide. The objective of this study is to increase the osteogenic capacity and hence, dental eruption.