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Cleft Lip and Palate clinical trials

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NCT ID: NCT05331456 Recruiting - Clinical trials for Cleft Lip and Palate

Alveolar Cleft Repair Using Osteoinductive Ceramics

ACROSTIC
Start date: June 1, 2022
Phase: N/A
Study type: Interventional

In this study, patients with unilateral cleft lip and palate are enrolled in a multicenter stepped wedge randomized trial ithat compares alveolar cleft closure using autologous bone harvested form the mandibular symphysis with an osteoinductive biphasic calcium phosphate putty.

NCT ID: NCT05081258 Recruiting - Clinical trials for Cleft Lip and Palate

Influence of Presurgical Orthodontic Molding on the Growth of Newborns With Unilateral Cleft Lip Palate

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

Orofacial clefts are the second most common birth deformity and vary in etiology and phenotype, e.g. isolated cleft palate, cleft lip or cleft lip palate. Especially newborns with unilateral complete cleft lip and palate (UCLP) present severe facial asymmetries auch as a broad and flat ala of the nose, a deviation of the columella and the philtrum to the non cleft side. Since postnatal asymmetries can even remain after surgical lip closure in a alleviated shape, therapeutic presurgical orthodontic approaches to improve symmetrie of the nose and to achieve ideal conditions for lip surgery are essential. Presurgical orthodontic treatment for newborns with UCLP start within the first days after birth to separate oral and nasal cavitiy, to improve breathing and feeding and to regulate growth of the maxillary segments using passive appliances (passive Alveolar Molding (pAM)). An advanced and widely spread concept is the Nasoalveolar Molding (NAM) by Grayson, which was first introduced in 1993 as a palate plate combined with a nasal stent as a non-invasive presurgical appliance to stimulate growth of the nose and use the postnatal potential to modulate the nasal cartilage. The aim of the NAM therapy is to reduce nasal width, to reduce deviation of the columella to the non cleft side and to increase nostril height. However, due to inhomogeneous study designs and results, so far only a slightly positive effect using NAM therapy could be detected and prospective, randomized clinical trials are necessary. The aim of the study is to analyse and to compare the effects of pAM versus NAM treatment in newborns with UCLP in the first year of life. The following parameters will be analysed on defined study time points: nostril width, nasal morphology, cleft width, maxillary growth, statical and dynamical facial asymmetries and facial perception.

NCT ID: NCT05031039 Not yet recruiting - Clinical trials for Cleft Lip and Palate

Skeletal and Dental Maturational Stages in a Sample of Egyptian Subjects With Cleft Lip and Palate Deformity

Start date: September 2021
Phase:
Study type: Observational

The aim of this research is to evaluate the skeletal and dental maturation of cleft lip and palate patients in a sample of Egyptian population using the CVM as indicator for the skeletal maturation and the Demirjian method as indicator for the dental one when compared to a group of Egyptian non-CLP subjects of the same age.

NCT ID: NCT05009472 Recruiting - Clinical trials for Cleft Lip and Palate

Rapid Maxillary Expansion and Protraction by Expander Differential Opening EDO in Cleft Lip and Palate Patients

Start date: June 26, 2021
Phase: N/A
Study type: Interventional

maxillary expansion in cleft palate patient with expander and using face mask.

NCT ID: NCT05002920 Completed - Clinical trials for Cleft Lip and Palate

Correlation Between Body Mass Index and Progressive Grafted Bone in Cleft Patients

Start date: January 25, 2021
Phase:
Study type: Observational

The cleft patients received alveolar bone graft(ABG) for alveolar defect. Body mass index (BMI) was measured for each patients when receiving ABG. Bone mineral density was measured by Cone-Beam CT at two time-points: post-ABG six months, and post-ABG two years. The study was to analyze the correlation between BMI and post-operative bone mineral density.

NCT ID: NCT04997083 Recruiting - Clinical trials for Cleft Lip and Palate

Slow Expansion and Protraction in Cleft Lip and Palate Patients

Start date: July 15, 2021
Phase: N/A
Study type: Interventional

Evaluate the treatment outcome of slow maxillary expansion protocol on patients with cleft lip and palate, using a differential opening expander and face mask which will be measured and recorded by cone beam computed tomography (CBCT).

NCT ID: NCT04987190 Completed - Clinical trials for Cleft Lip and Palate

Progression of Grafted Bone Density in Cleft Alveolus

CDAABG
Start date: January 25, 2021
Phase:
Study type: Observational

The patients with unilateral and bilateral cleft lip and palate received alveolar bone graft surgery. Two time points of cone beam CT were taken for all the patients: post-operative 6 months, and post-operative 2 years. All the CT images were reviewed for the analysis of grafted bone density.

NCT ID: NCT04970095 Recruiting - Clinical trials for Cleft Lip and Palate

Alt-RAMEC Expansion and Protraction by EDO in Cleft Lip and Palate Patient

Start date: July 15, 2021
Phase: N/A
Study type: Interventional

Evaluate the treatment outcome of Alternate Rapid Maxillary Expansion and Constriction Alt-RAMEC protocol on patients with cleft lip and palate, using a differential opening expander and face mask which will be measured and recorded by cone beam computed tomography (CBCT).

NCT ID: NCT04966572 Recruiting - Clinical trials for Cleft Lip and Palate

Short Term Efficiency of Presurgical Vacuum Formed Nasoalveolar Molding Aligners in Infants With Bilateral Cleft Lip and Palate Compared With Grayson Acrylic Formed Nasoalveolar Molding Appliances.

Start date: March 1, 2021
Phase: N/A
Study type: Interventional

Newborns with bilateral cleft lip/ palate will be treated pre-surgically by either presurgical vacuum-formed nasoalveolar molding aligners VF (NAM) or conventional Grayson acrylic formed nasoalveolar molding appliances in order to evaluate their effect on the maxillary arch.

NCT ID: NCT04791813 Not yet recruiting - Clinical trials for Cleft Lip and Palate

Assessment of Maxillary Arch Depth and Width in a Group of Surgically Repaired Unilateral Cleft Lip and Palate Children Versus Normal Children .

Start date: March 2022
Phase:
Study type: Observational

The aim of the present study is to determine the effect of surgically repaired UCLP on dental arch dimensions and the need for orthodontic intervention in comparison with other healthy children , the presence of dental anomalies and the best possible standards of care among this group of Egyptian children.