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Clinical Trial Summary

Study to test the effect of the drug "L-ornithine.L-aspertate" (LOLA) on microorganisms in the digestive tract in patients with liver cirrhosis (damage of the liver due to liver disease)


Clinical Trial Description

Liver cirrhosis is associated with gut microbiome dysbiosis, which may drive intestinal inflammation, gut barrier dysfunction and the development of complications. LOLA is a well-established drug against elevated ammonia levels that contribute to hepatic encephalopathy and sarcopenia. In a recent retrospective study, LOLA has been shown to improve gut microbiome dysbiosis. In this study we aim to investigate whether LOLA therapy over three months in patients with liver cirrhosis (irrespective of the etiology) and covert or overt hepatic encephalopathy (HE) leads to an improvement in gut microbiome dysbiosis, as well as markers of gut permeability, inflammation, muscle function and ammonia levels. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05737030
Study type Interventional
Source Medical University of Graz
Contact Angela Horvath
Phone 0043 316 385
Email angela.horvath@cbmed.at
Status Recruiting
Phase Phase 4
Start date February 6, 2023
Completion date December 2025

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