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Clinical Trial Summary

Prospective randomized, multi-center, double blind placebo-controlled trial to assess the chemopreventive impact of atorvastatin (20 mg oral) vs placebo in up to 60 adults with advanced fibrosis at high risk of developing HCC.

Clinical Trial Description

The study objective is to investigate the chemopreventive efficacy of atorvastatin (20 mg) on HCC risk compared to placebo in adults with advanced fibrosis (i.e. METAVIR fibrosis stage 3-4) and high-risk PLS (defined by pre-randomization liver biopsy). HCC risk will be measured by changes in prognostic liver signature (PLS) risk score after oral administration of atorvastatin for 1 year with up to 5 years post-treatment of chart monitoring. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05028829
Study type Interventional
Source Massachusetts General Hospital
Contact Raymond Chung, MD
Phone 617-724-7526
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date November 2021
Completion date February 2028

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