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Decompensation of Cirrhosis and Iron Metabolism — DeCiFer  

Cirrhosis Clinical Trial

Official title:
Decompensation of Cirrhosis and Iron Metabolism

Clinical Trial Summary

Iron is a crucial metal whose metabolism is tightly regulated. Iron deficiency or iron overload are both deleterious at the cellular, organic and systemic levels. In line with the major role of the liver in iron homeostasis, links between iron metabolism and acute on chronic liver failure have been highlighted. Nevertheless, due to the difficulty of accurately assessing iron metabolism in this situation, therapeutic intervention on iron metabolism in this setting is currently not codified. A better understanding of these mechanisms is therefore essential, in particular by characterizing the impact of exposure to non-transferrin-bound iron in acute on chronic liver failure on short-term mortality. Overall, a better understanding of the physiopathological mechanisms of iron should allow to optimize the martial balance in this condition and also improve therapeutic approaches.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04807023
Study type Observational
Source Rennes University Hospital
Contact Mevel Nicolas
Phone 02 99 28 25 55
Email dri@chu-rennes.fr
Status Recruiting
Phase
Start date May 17, 2021
Completion date November 2022
View Details
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