Cirrhosis Clinical Trial
Official title:
To Assess the Efficacy of Granulocyte Colony Stimulating Factor Versus Standard Medical Therapy in Patients of Decompensated Cirrhosis
Background and Aims: Liver transplantation is the only curative treatment modality for
decompensated cirrhosis and is limited by donor organ availability and financial resources;
thus many patients die while awaiting liver transplant. Granulocyte colony stimulating
factor (GCSF) therapy can mobilize bone marrow stem cells for tissue regeneration, and has
been shown to benefit patients with liver disease. The investigators evaluated the efficacy
of GCSF therapy in decompensated cirrhosis in an open labelled randomized control trial.
Patients and Methods: Consecutive patients with decompensated cirrhosis of mixed etiologies
were randomized to receive either a 5-day course of GCSF (5 μg/kg/d) plus standard medical
therapy for 6 months (Group-A); or standard medical therapy alone for 6 months (Group-B). At
the end of 6 months their survival were compared.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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