Cirrhosis Clinical Trial
Official title:
Effect of Transjugular Intrahepatic Portosystemic Shunt on Gut Microbiota and Associated Inflammatory Factors in Cirrhotic Patients
The purpose of this study is to determine the effect of transjugular intrahepatic portosystemic shunt on gut microbiota and associated inflammatory factors in cirrhotic patients.
Cirrhosis is associated with qualitative and quantitative changes in the gut microbiota that
can potentiate disease progression and complications such as hepatic encephalopathy (HE) and
infections. Dysbiosis or altered gut microbiota, due to decreased autochthonous or commensal
taxa, has been found in stool and colonic mucosa in cirrhotic patients, which is in turn
linked with disease severity and systemic inflammation.
TIPS can decompress the hypertensive portal vein,so that the intestinal congestion can be
decrease too. Hence we summarize that TIPS may have effect on gut microbiota and associated
inflammatory factors in cirrhotic patients.
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Observational Model: Cohort, Time Perspective: Prospective
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