Echocardiographic Assessment of Intrapulmonary Vasodilatation: Agitated Saline Versus Polygeline

Cirrhosis Clinical Trial

Official title:

Evaluation of Two Methods for the Echocardiographic Assessment of Intrapulmonary Vasodilatation in Patients With Liver Cirrhosis: Agitated Saline Versus Polygelatine

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00343122
• Other study ID #: EK 4462005
• Status: Recruiting
• Phase: Phase 4
• First received: June 20, 2006
• Last updated: September 14, 2007
• Start date: June 2006

Study information

• Verified date: September 2007
• Source: Medical University of Vienna
• Contact: Valentin Fuhrmann, MD
• Phone: 0043-1-40400
• Email: valentin.fuhrmann[@]meduniwien.ac.at
• Is FDA regulated: No
• Health authority: Austria: Federal Ministry for Health and Women
• Study type: Observational

Clinical Trial Summary

The purpose of the study is to evaluate agitated saline versus polygeline for detection of intrapulmonary vasodilatation in patients with cirrhosis.

Description:

Intrapulmonary vasodilatation is a frequent finding in patients with cirrhosis. Its diagnosis is established via contrast enhanced echocardiography. One used method is the contrast agent agitated saline and another frequently used method is the contrast agent polygeline. The purpose of this study is to compare these two echocardiographic contrast agents with respect to their ability to detect intrapulmonary vasodilatation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• age > 18 years

• presence of liver cirrhosis

• evaluation for liver transplantation or transjugular intrahepatic portosystemic shunt

Exclusion Criteria:

• inadequate echocardiographic image quality

• allergies to echocardiographic contrast agents

• pulmonary valve stenosis

• pulmonary embolism

• relevant tricuspid regurgitation

• cardiomyopathy

Study Design

Observational Model: Defined Population, Time Perspective: Longitudinal

Related Conditions & MeSH terms

• Cirrhosis
• Liver
• Liver Cirrhosis

Intervention

Procedure:
• echocardiography for intrapulmonary vasodilatation

Locations

Country	Name	City	State
Austria	Intensive Care Unit 13H1, Dep. of Internal Medicine IV, Medical University of Vienna	Vienna

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

References & Publications (1)

Rodríguez-Roisin R, Krowka MJ, Hervé P, Fallon MB; ERS Task Force Pulmonary-Hepatic Vascular Disorders (PHD) Scientific Committee. Pulmonary-Hepatic vascular Disorders (PHD). Eur Respir J. 2004 Nov;24(5):861-80. Review. — View Citation