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Cigarette Smoking clinical trials

View clinical trials related to Cigarette Smoking.

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NCT ID: NCT01692353 Completed - Clinical trials for Cardiovascular Disease

Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers

Start date: September 2008
Phase: N/A
Study type: Observational

This cross-sectional study was primarily a cardiovascular disease (CVD) study designed a) to compare selected CVD biomarker data between subjects who were long-term consumers of cigarettes or moist snuff and non-consumers of tobacco and b) to identify principal endpoints related to CVD risk that differed among the three tobacco-use cohorts. The following assessments provided the primary study endpoints for comparative analyses between the cohorts: 1. CVD-related physiological assessments: Flow-mediated dilation (FMD), carotid intima-media thickness (CIMT), ankle-brachial index (ABI), spirometry and expired carbon monoxide (ECO). 2. CVD-related biomarker assessments in blood and urine (biomarkers of tobacco effect). 3. Biomarkers of tobacco exposure in urine and blood.

NCT ID: NCT01639079 Completed - Nicotine Dependence Clinical Trials

Comparison of Internet Stop Smoking Intervention to Usual Care on Smoking Cessation at 6 Months

TC5Redes
Start date: June 2012
Phase: N/A
Study type: Interventional

The primary goal of this project is to carry out a randomized controlled trial (RCT) comparing quit rates of a Spanish/English stop smoking Web site to those of a no-intervention or "quit on your own" control. The investigators have not included a no-intervention condition in previous Web studies and although 20% of participants quit smoking at one year are 20%, obtaining evidence that the investigators interventions yield higher abstinence rates than a no-intervention control is the next logical step. Furthermore, although the investigators Web site was designed in English and Spanish, the investigators success in attracting the U.S. Hispanic/Latino (HL) population in either language has been limited, so this project only will only conduct intensive telephone follow-up of HL smokers and add new recruitment methods to do so.

NCT ID: NCT01633567 Completed - Cigarette Smoking Clinical Trials

Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers

Start date: May 2012
Phase: N/A
Study type: Interventional

For the approximately 4.6 million LGBT persons in the U.S., smoking rates among those living in urban areas are roughly twice that of heterosexuals. Targeted interventions have shown great promise in reducing health risk behaviors across a variety of behaviors and population groups by enhancing the relevance of the health information. The primary aim of this study is to test the efficacy of a culturally targeted group-based smoking cessation intervention (vs. a non-targeted intervention) on smoking outcomes among lesbian, gay, bisexual, and transgender (LGBT) smokers. The investigators anticipate that the culturally targeted intervention will be more effective at helping LGBT smokers to successfully stop smoking than will the non-targeted intervention.

NCT ID: NCT01627392 Completed - Cigarette Smoking Clinical Trials

Mechanisms of the Nicotine Metabolism Effect on Tobacco Dependence

NMR
Start date: July 2012
Phase: N/A
Study type: Interventional

The purpose of the study is to learn more about tobacco dependence and nicotine metabolism in African-Americans and whites, by studying to see if how fast a person metabolizes nicotine (how the body breaks down nicotine into inactive compounds) affects how dependent they are on smoking cigarettes. The investigators believe that people with a faster rate of metabolism may have more severe nicotine withdrawal symptoms and also may have a harder time trying to quit smoking.

NCT ID: NCT01604525 Completed - Cigarette Smoking Clinical Trials

Tailored Web and Peer Email Cessation Counseling for College Smokers

RealU
Start date: May 2011
Phase: N/A
Study type: Interventional

The RealU2 is a randomized controlled trial to determine the efficacy of an online health and wellness program for young adults with the addition of individualized peer health coaching.

NCT ID: NCT01596556 Completed - Cigarette Smoking Clinical Trials

The Effect of Smoking on Thermoregulation

Start date: June 2012
Phase: N/A
Study type: Interventional

To the best of our knowledge, a possible relation between smoking and heat injuries or heat intolerance was never scientifically examined, although such a relation is logical according to the observations that smoking has a thermogenic effect, decreases physical fitness and affects the body's heat dissipation.16 healthy young male volunteers will participate in the study, 8 smokers and 8 non-smokers. They will arrive to our lab four or six times. They will perform VO2 test and heat tolerance test (HTT) in different conditions.

NCT ID: NCT01592695 Completed - Cigarette Smoking Clinical Trials

Tailored Tobacco Quitline for Rural Veterans

Start date: June 2012
Phase: Phase 2
Study type: Interventional

The proposed work is designed to help increase access to tobacco cessation services among rural veterans and to develop more effective treatment services that better address comorbid issues commonly experienced by rural smokers. The objectives are: 1. Study the feasibility of an individually-tailored telephone intervention for rural smokers. 2. Examine the impact of the intervention on tobacco use outcomes. 3. Evaluate the effect of the intervention on issues commonly experienced by rural smokers including depressive symptoms, alcohol use, and weight gain.

NCT ID: NCT01566097 Active, not recruiting - Smoking Cessation Clinical Trials

Intervention Trial of Culturally-Appropriate Decision Aids for Smoking Cessation

Start date: April 2012
Phase: N/A
Study type: Interventional

Despite the establishment of various smoking cessation methods, including pharmacological intervention, only a small proportion of smokers who visit doctors choose to receive such assistance. Such under-utilization is especially apparent in some cultures, as in the case of Korea, where a government survey showed that only 0.5% of current or formal smoker reported they had been prescribed smoking cessation medication. Shame in asking for help for an addictive disorder has been recognized as one of the most recognized cultural barrier in Asian-American population. It is clear that culturally focused studies on smoking cessation is warranted. Patient decision aids are tools that help people become involved in decision making by providing information about the options and outcomes and by clarifying personal values. Patient decision aids have been developed to help patients decide whether to quit smoking or not, or whether to use smoking medication or not. However, such previous studies have only been focused on western populations. The main purpose of this study is to develop a culturally appropriate decision aid for smoking cessation for the Korean population, as well as evaluate its effect on their decision to use smoking cessation medication. The investigators expect that culturally tailored smoking cessation decision aids would increase knowledge about efficacy of smoking cessation, make people have more positive attitudes toward smoking cessation medication, encourage people to discuss about smoking cessation medication with their physicians. Ultimately the investigators expect it would increase usage of smoking cessation medication and enhance the quitting rate of smoking, which is a very important clinical issue.

NCT ID: NCT01560507 Terminated - Nicotine Dependence Clinical Trials

Tailored Smoking Cessation Treatment for LIVE FOR LIFE® Participants

LiveForLife2
Start date: May 2012
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to ascertain: 1) the rate of smoking cessation obtained using an adaptive treatment algorithm developed in previous clinical trials, in order to calculate cost-effectiveness of the treatment; 2) the relationship between genotype and response to cigarette smoking cessation treatment.

NCT ID: NCT01526005 Completed - Cigarette Smoking Clinical Trials

Brain Nicotine Receptor Density & Response to Nicotine Patch

Start date: March 2012
Phase: Phase 3
Study type: Observational

Even though the health risks and societal costs of cigarette smoking are well-known, roughly 19.8% of American adults continue to smoke. While most smokers endorse a desire to quit, very few (< 5%) will actually quit in a given year without treatment, and only about 20-25% achieve abstinence after 6 months or more of effective treatment. Therefore, there continues to be a vital need to improve outcomes for cigarette smokers seeking treatment. Current first-line medications for Tobacco Dependence include nicotine replacement therapies (such as the patch, gum, lozenge, nasal spray, and inhaler), varenicline HCl (Chantix), and bupropion HCl (Zyban), with the current standard of care in most treatment settings being to choose specific medications based primarily on availability, ease of use, and patient preference. The goal of the proposed research is to improve the delivery of smoking cessation treatment by determining if pre-treatment nicotine receptor density in cigarette smokers is associated with smoking cessation outcome with the standard nicotine patch taper. The study's main hypothesis is that cigarette smokers with less pre-treatment upregulation of nicotine receptors will have a greater likelihood of quitting smoking from a standard course of nicotine patch treatment than smokers with more up-regulation of these receptors. Positron emission tomography (PET) will be used to test this hypothesis.