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Cicatrix clinical trials

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NCT ID: NCT00691769 Completed - Clinical trials for Discoid Lupus Erythematosus

Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia

Start date: April 26, 2006
Phase:
Study type: Observational

The purpose of this research study is to see if a specific protein that we are interested in is involved in scarring hair loss. If these proteins are involved, further genetic work may also better define the disease as well as future treatment options.

NCT ID: NCT00685243 Completed - Post Surgical Scars Clinical Trials

Treatment of Surgical Scars With Fractional Photothemolysis Versus Pulse Dye Laser

Start date: January 2008
Phase: N/A
Study type: Interventional

1. Evaluate the efficacy of the Fraxel SR laser to improve the cosmetic appearance of surgical scars, both in terms of pigmentary and textural changes. 2. Evaluate the efficacy of the V-Beam Pulse Dye laser, a standard non-ablative laser which is utilized for the treatment of the erythematous and telangiectasia component of surgical scars. 3. Comparison of the outcome of the half of the surgical scar treated with Fraxel SR laser versus the outcome of the contralateral half of the surgical scar which will be treated with the V-Beam Pulse Dye Laser.

NCT ID: NCT00651820 Completed - Scarring Clinical Trials

Effect of Collagenase on Healing and Scarring

Start date: April 2008
Phase: Phase 4
Study type: Interventional

A study to compare the rate of complete wound closure and quality of resulting scar at 3, 6 and 9 months, between dermatome-induced skin wounds treated with Collagenase Santyl Ointment versus vehicle alone.

NCT ID: NCT00642642 Completed - Clinical trials for Acne Scarring of the Face

Safety and Efficacy Study of Autologous Fibroblasts in the Treatment of Severe Facial Acne Scarring

Start date: November 2007
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the safety profile and the treatment effect of Isolagen TherapyTM and placebo when administered to facial acne scars.

NCT ID: NCT00641420 Completed - Acne Scarring Clinical Trials

Safety and Efficacy of 1550nm Fractional Laser Treatment for Acne Scars in Fitzpatrick Type IV-VI Skin

Start date: September 2007
Phase: N/A
Study type: Interventional

Fractionated laser resurfacing is commonly used as a treatment for acne scarring in fair skinned individuals. This study aims to test the efficacy and safety in darker skin types. Patients are randomized to either the 10mJ 40mJ dosages and receive a total of five treatments at 17% one month apart. Improvement is judged by a dermatologist as 0-25%, 25-50%, 50-75% or 75-100%. Side effects such as pigmentary abnormalities and pain are also evaluated.

NCT ID: NCT00629811 Completed - Cicatrix Clinical Trials

Improvement in Scar Appearance Following Injection of Avotermin (Juvista) Into Skin Incisions Made in Healthy Men and Women

Start date: September 2006
Phase: Phase 2
Study type: Interventional

This is a single-centre, double-blind, Placebo-controlled, randomised trial. Trial subjects received four 1cm incisional wounds on the inner aspect of each upper arm (eight in total), giving four pairs of anatomically matched wound sites per subject. Each subject acted as their own control. One site from each anatomical wound pair was randomly treated with intradermally administered avotermin (Juvista:100μL per linear cm of wound site pre-operatively and 100μL per linear cm of wound margin post-wounding on Day 0 or Day 1, 400μL per wound site) while the second site was a paired control, treated with Placebo (100μL per linear cm of wound site pre-operatively and 100μL per linear cm of wound margin post-wounding on Day 0 or Day 1, 400μL per wound site). Wound margins for injection were defined as extending 0.5cm from either end of the incision. Four doses of avotermin (Juvista) were administered to each subject: 5ng, 50ng, 200ng and 500ng/100μL per linear cm; one dose to one wound site per anatomically matched pair of wounds. The second wound site from each anatomically matched pair of wounds was dosed with placebo. Allocation of treatment to wound-site pairs was randomised and double blinded. Primary objective To determine the optimal concentration and dose regimen of Juvista for the improvement of the resultant scar when applied to the approximated wound margins of male and female subjects following surgical incisions. Secondary objective To assess the safety and tolerance of Juvista when applied to the approximated wound margins of male and female subjects following surgical incisions.

NCT ID: NCT00627536 Completed - Cicatrix Clinical Trials

Scar-Improvement Efficacy and Safety of a Single Intradermal Injection of Avotermin (Juvista) Administered Following Full-Thickness Skin Incisions

Start date: July 2006
Phase: Phase 2
Study type: Interventional

This study was undertaken to investigate the scar-improvement efficacy and safety of a single dose of avotermin (Juvista) injection into skin incisions.

NCT ID: NCT00594581 Completed - Cicatrix Clinical Trials

Anti-Scarring Efficacy and Safety of Intradermal Juvista (Avotermin) in Healthy Males

Start date: October 2003
Phase: Phase 2
Study type: Interventional

This study was undertaken to investigate safety and scar-improvement activity of different applications of Juvista (avotermin), administered to surgical incisions made to the skin of a healthy population of male volunteers aged 18-45 years. The study addressed two issues: whether Juvista (avotermin) administered at 200ng/100μl/linear cm wound margin is more effective than 50ng/100μl/linear cm for scar improvement and, secondly, whether dosing once only (before wounding) or twice (before and after wounding) is optimal for scar improvement.

NCT ID: NCT00510055 Completed - Acne Scarring Clinical Trials

Treatment of Acne Scarring With a Novel Procedure Combination

Start date: June 2007
Phase: N/A
Study type: Interventional

The primary objective of this study is to look at the efficacy of subdermal manipulation and filler injection in the improvement of acne scar appearance.

NCT ID: NCT00482144 Completed - Cicatrix Clinical Trials

Study of the Effects of the Pulsed-dye Laser at 585nm and 595nm to Treat Post-operative Scars on Suture-removal Day

Start date: July 2003
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the effects of the pulsed-dye laser (PDL) at two different wavelengths, 585nm and 595nm, in the treatment of post-surgical scars starting on suture-removal day.