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Rate Adaptive Atrial Pacing in Heart Failure — ADAPTION  

Heart Failure Clinical Trial

Official title:
Rate Adaptive Atrial Pacing in Heart Failure Patients With Chronotropic Incompetence

Clinical Trial Summary

The ADAPTION trial is an investigator initiated prospective randomized doubleblind cross-over pilot study in a multi-center setting.

Aim: to assess the ability of minute ventilation (MV) sensor driven rate adaptive atrial stimulation to restore functional capacity and quality of life in heart failure patients with chronotropic incompetence.

Methods: heart failure patients (left ventricular ejection fraction ≤35% & New York Heart Assessment II or III) who were implanted with a 2-chamber implantable cardioverter defibrillator (ICD) device equipped with a MV sensor that are diagnosed with chronotropic incompetence will be included in the study. Patients will be randomized in a 1:1 fashion to rate responsive pacing (MV sensor only) function ON (AAIR mode) or OFF (DDI mode). After 3 months the pacing mode will be switched to the opposite mode.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03235843
Study type Interventional
Source VU University Medical Center
Contact Cornelis P Allaart, MD, PhD
Phone +31 (0)20 4445043
Email cp.allaart@vumc.nl
Status Recruiting
Phase N/A
Start date August 1, 2017
Completion date December 1, 2019
View Details
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