Obesity Clinical Trial
Official title:
Chronobiology and Childhood Obesity in a Mediterranean Spanish Population (ONTIME-JR: Obesity, Nutrigenomics, Timing, Mediterranean, Junior)
The main objective is to investigate chronobiological aspects of childhood obesity studying the potential relationship between meal patterns and circadian rhythmicity in a cross-sectional sample of obese, overweight and normal weight children/adolescent.
Childhood obesity has more than doubled in children and tripled in adolescents in the past 30
y. As consequence, increasingly children and adolescents suffer from elevated blood pressure,
impaired glucose tolerance, hyperinsulinemia, dyslipidemia. Obesity has a multifactorial
etiology since there are potentially numerous contributors to its development and
progression. Chronobiology, the science that studies periodic (cyclic) changes in living
organisms, has been recently proposed as a new and promising topic to investigate.
Alterations of circadian (24 h oscillations) system may contribute to obesity and its
complications development such as high blood pressure, insulin resistance, altered fasting
lipid profile. Conversely, in a vicious manner, obesity has been regarded as a fault in the
circadian system explainable by the association with imbalances and fluctuations of
hormones/genes expressions rhythms under the influence of body weight changes.
Thus, the study will examine changes in circadian rhythmicity over a week period. The primary
end point will be to evaluate differences between obese/overweight and non-obese children in
chronotypes and the responses of these parameters to meal patterns. In particular,
non-invasive measures that are well-established determinants of chronotypes will form the
core endpoints for the study. Well designed and age-appropriate questionnaires will provide
further information in order to study correlations with eating, sleeping and sedentary/active
behaviors.
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