Acute Steroid Responsive Dermatoses Clinical Trial
Official title:
An Investigator-Initiated Study to Assess the Cooling Effect of Triamcinolone Acetonide Aerosol When Used for Steroid-Responsive Dermatoses
Triamcinolone acetonide is a mid-potency, class 4/5 topical corticosteroid that is available
in a spray formulation (Triamcinolone Acetonide Spray, T Spray). It is indicated for the
relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Unlike more potent steroid products, T Spray has no time limitations on its use; therefore,
it is commonly used to treat flares in psoriasis, atopic dermatitis, seborrheic dermatitis,
and contact dermatitis.
In contrast to creams and ointments, T Spray can easily cover large and hard-to-reach areas
of the body. Its optional nozzle directs application of the medication to precise areas
without affecting nearby areas. Patients requiring a mid-potency corticosteroid for lesions
on the scalp, back, intertriginous folds, large areas, or areas that require precise
application would benefit from the T Spray formulation. In the time since the introduction
of T Spray to dermatology, other topical corticosteroids have entered the market, but T
Spray remains the only mid-potency corticosteroid available in a spray formulation.
In a recently published open-label, non-comparator study involving 42 patients with chronic
steroid-responsive dermatoses, T Spray was used up to four times a day for 28 days.
Improvement of lesions after one week of treatment was experienced by 85% of patients, and
95% of subjects preferred the spray over creams and ointment. Most importantly, 56% of
patients reported an anti-pruritic cooling effect which was experienced upon application.
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science