Chronic Rhinosinusitis Clinical Trial
Official title:
Correlation Between Middle Turbinate Histopathology and Computed Tomography Staging in Chronic Rhinosinusitis
In a previous study (Berger el al. Old and new aspects of middle turbinate histopathology.
Otolaryngol Head Neck Surg. 2009;140:48-54), the investigators reported significant
histopathologic changes in the middle turbinate mucosa of patients with chronic
rhinosinusitis compared with normal controls. However, patients' mean Lund-MacKay CT score
was 6.5±6.7 and were considered as having a relatively limited sinus disease (a score of
1-8). Nine to sixteen was considered as intermediate sinus disease, and 17-24 extensive. No
osteomyelitic changes were seen in this study group.
The investigators hypothesize that a comparison between the three groups of patients with
chronic rhinosinusitis having limited, intermediate, and extensive sinus disease would show
that the higher the CT staging, the greater the histopathologic changes of the middle
turbinate. The investigators also expect to find osteomyelitic changes in the middle
turbinate of patients with higher CT staging.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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