Chronic Rhinosinusitis Clinical Trial
Official title:
Correlation Between Middle Turbinate Histopathology and Computed Tomography Staging in Chronic Rhinosinusitis
In a previous study (Berger el al. Old and new aspects of middle turbinate histopathology.
Otolaryngol Head Neck Surg. 2009;140:48-54), the investigators reported significant
histopathologic changes in the middle turbinate mucosa of patients with chronic
rhinosinusitis compared with normal controls. However, patients' mean Lund-MacKay CT score
was 6.5±6.7 and were considered as having a relatively limited sinus disease (a score of
1-8). Nine to sixteen was considered as intermediate sinus disease, and 17-24 extensive. No
osteomyelitic changes were seen in this study group.
The investigators hypothesize that a comparison between the three groups of patients with
chronic rhinosinusitis having limited, intermediate, and extensive sinus disease would show
that the higher the CT staging, the greater the histopathologic changes of the middle
turbinate. The investigators also expect to find osteomyelitic changes in the middle
turbinate of patients with higher CT staging.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04131686 -
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
|
||
| Completed |
NCT02692794 -
Large Scale Cerebral Oximetry During Sinus Endoscopy
|
N/A | |
| Completed |
NCT01988779 -
Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
|
Phase 3 | |
| Completed |
NCT01254916 -
The Sinonasal Outcome Test - 22, Validated for Danish Patients
|
N/A | |
| Completed |
NCT03614923 -
Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
|
Phase 2 | |
| Completed |
NCT03781804 -
Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps
|
Phase 3 | |
| Completed |
NCT01198912 -
Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
|
Phase 2 | |
| Completed |
NCT03280537 -
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
|
Phase 3 | |
| Completed |
NCT02307825 -
Azithromycin for Patients With Chronic Rhinosinusitis Failing Medical and Surgical Therapy
|
Phase 4 | |
| Terminated |
NCT02285283 -
Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps
|
Phase 2/Phase 3 | |
| Completed |
NCT02218307 -
The Use of Antibiotic Sinonasal Rinse After Sinus Surgery
|
Phase 4 | |
| Recruiting |
NCT01024075 -
Effect of Sinufoam-Dexamethasone Mixture on Post Endoscopic Sinus Surgery Outcomes
|
Phase 4 | |
| Completed |
NCT01002313 -
Effect of Prednisone onTregs and TH17
|
Phase 1 | |
| Completed |
NCT00396162 -
Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis
|
Phase 4 | |
| Completed |
NCT03280550 -
A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 3 | |
| Recruiting |
NCT05935683 -
Rhinosinusitis Italian Network: the Italian Registry for Severe, Uncontrolled Chronic Rhinosinusitis
|
||
| Completed |
NCT03478930 -
An Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 3 | |
| Completed |
NCT01943370 -
Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement
|
N/A | |
| Completed |
NCT02154555 -
A Randomized Controlled Trial Evaluating Postoperative Debridement Following Endoscopic Sinus Surgery
|
N/A | |
| Completed |
NCT01778465 -
Effect of Dietary Salicylate in Aspirin Exacerbated Respiratory Disease
|
N/A |