Chronic Rhinosinusitis With Nasal Polyps Clinical Trial
Official title:
Predictive Factors in Chronic Rhinosinusitis With Nasal Polyps
The study will be conducted to identify factors predicting the response of chronic rhinosinusitis with nasal polyps ( CRSwNP) to oral corticosteroids.
Treatment of nasal polyposis is divided into medical or surgical treatment . Steroids are widely used as the most effective medicine in nasal polyposis. Although oral corticosteroids are one of the frequently used treatments in the management of chronic rhinosinusitis with nasal polyps (CRSwNP), there is lack of effective means of predicting corticosteroid sensitivity in those patients. It was reported that the overall sensitivity rates of corticosteroid therapy to nasal polyps( NP) were only between 53.8% and 80%.. Many reports stated that serum and tissue interleukeine 25 (IL 25) and serum and tissue eosinophalia are good predictors to the response of CRSwNP to oral corticosteroids. Interleukeine 25(IL-25), an important epithelial-derived proinflammatory cytokine, plays various roles in different inflammatory and allergic diseases, such as asthma and atopic dermatitis . Hong et al demonstrated that the levels of IL-25 in NP tissues and in serum, as well as the NP endoscopic scores, were significantly elevated in the corticosteroid-sensitive patients compared with the non-sensitive ones. In general, eosinophilic NPs are pharmacologically glucocorticoid responsive, but non-eosinophilic or neutrophilic CRSwNP is frequently resistant to steroid treatment. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05895929 -
The Role of IL5 in Epithelial Cell Integrity
|
Early Phase 1 | |
| Active, not recruiting |
NCT05891483 -
Efficacy and Safety of SHR-1905 Injection in Patients With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 2 | |
| Active, not recruiting |
NCT04998604 -
EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients
|
Phase 4 | |
| Recruiting |
NCT06069310 -
Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma
|
||
| Recruiting |
NCT05009758 -
Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps
|
N/A | |
| Active, not recruiting |
NCT05529784 -
Dupilumab in the Treatment of Severe Uncontrolled CRSwNP: a Multicentre Observational Real-life Study (DUPIREAL)
|
||
| Recruiting |
NCT05902325 -
Identifying Predictors Of Response To Mepolizumab In CRSwNP
|
Phase 4 | |
| Completed |
NCT05049122 -
Dupilumab in Japanese Patients With Chronic Rhinosinusitis With Nasal Polyp (SINUS-M52)
|
Phase 4 | |
| Not yet recruiting |
NCT05598411 -
CST1-Guided Oral Glucocorticoids Management for CRSwNP
|
Phase 4 | |
| Active, not recruiting |
NCT05553951 -
Adherence in Global Airways
|
N/A | |
| Recruiting |
NCT05131464 -
The Study of CM310 in Patients With Chronic Rhinosinusitis With Nasal Polyps
|
Phase 2 | |
| Recruiting |
NCT05598424 -
CST1 Predictive Model of Oral Glucocorticoid Therapy Sensitivity for Chronic Rhinosinusitis With Polyps
|
Phase 4 | |
| Active, not recruiting |
NCT05649813 -
A Study in Male and Female Adult Participants With Chronic Rhinosinusitis With Nasal Polyps In the Greater Gulf Region
|
||
| Recruiting |
NCT04628442 -
Tissue Immune Interaction in Nasal Polyposis
|
||
| Active, not recruiting |
NCT06118554 -
3D Printing to Improve Nasal Irrigation Outcome
|
N/A | |
| Active, not recruiting |
NCT04596189 -
Dupilumab for Prevention of Recurrence of CRSwNP After ESS
|
Phase 4 | |
| Recruiting |
NCT02668861 -
Effect of Oral Vitamin D3 on Chronic Rhinosinusitis Treatment in Adults With Lower Vitamin D Levels
|
Phase 3 | |
| Active, not recruiting |
NCT05878093 -
Dupilumab in Chinese Adult Participants With CRSwNP
|
Phase 3 | |
| Completed |
NCT05931744 -
The Role of Budesonide Intrapolyp Injection in the Management of Type 2 Chronic Rhinosinusitis
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05938972 -
Real Life Study of Biologicals in Patients With Severe CRSwNP
|