Correlation Between the Microbiome and Type 2 Inflammatory Diseases of CRSwNP

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) Clinical Trial

Official title: A Study on the Correlation Between the Microbiome and Type 2 Inflammatory Diseases of Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Status Not yet recruiting

Clinical Trial Summary

Nasal microorganisms, exfoliated cells, nasal secretions, fetal microorganisms and blood were collected from patients with chronic sinusitis with nasal polyps before medication. Nasal polyp tissues of the patients were clamped for pathologic biopsy in the outpatient clinic. Methylprednisolone was then administered to the patients for 17 days, and the nasal microbial changes were observed after the administration of the drug. Patients underwent surgical treatment after the administration of the drug, and postoperative patients were followed up for a long period of time until polyp recurrence. During the follow-up, the microorganisms in the patients' postoperative nasal cavities were collected and the postoperative microbial changes were recorded

Clinical Trial Description

In this study, we retrospectively collected pathologic paraffin specimens and patient information from previous cases of sinusitis with nasal polyps, and prospectively collected specimens from newly enrolled patients with nasal polyps. ;

Related Conditions & MeSH terms

• Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
• Nasal Polyps
• Polyps

• NCT number: NCT06231004
• Study type: Observational
• Source: The First Affiliated Hospital with Nanjing Medical University
• Contact: Lei Cheng, Phd
• Phone: 0086-13776620807
• Email: chenglei@jsph.org.cn
• Status: Not yet recruiting
• Start date: January 22, 2024
• Completion date: September 1, 2032