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The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammatory Phenotype

Chronic Rhinosinusitis (Diagnosis) Clinical Trial

Official title:
The Causal Relation of Nasal Nitric Oxide Levels to the Severity of Chronic Rhinosinusitis and Its Inflammatory Phenotype

Clinical Trial Summary

Nitric oxide (NO) reflects changes in inflammatory state of the airways. In pulmonology fractional exhaled nitric oxide concentration (FeNO) has been linked to eosinophilic asthma and is used to guide overall disease control. The measurement of nasal nitric oxide (nNO) may reflect the disease burden and inflammatory phenotype of the paranasal sinuses. The aim of our study is to evaluate the relation of chronic rhino sinusitis (CRS) severity and inflammatory status to nNO, maxillary sinus NO, nitrite, nitrate and cone beam computed tomography (CBCT). Three groups (22 patients in each) of referred patients and and 22 healthy volunteers are recruited. Patients are grouped according to the CBCT score and viewed three times in 4-6 weeks intervals.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Chronic Rhinosinusitis (Diagnosis)
  • Sinusitis
Clinical Trial Details
NCT number NCT04171167
Study type Interventional
Source Tampere University Hospital
Contact
Status Active, not recruiting
Phase N/A
Start date April 4, 2017
Completion date December 2026
View Details
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