Clinical Impact of Patient-ventilator Asynchrony

Status Recruiting

Clinical Trial Summary

The investigator wish to carry out this study to explore the link between patient-ventilator asynchrony with the efficiency and tolerance of NIV but also the quality of life in patients with chronic respiratory failure on long-term ventilation.

Clinical Trial Description

Chronic respiratory failure (CRF) is an advanced stage of many respiratory diseases marked by an inability of the respiratory system to ensure vital gas exchange. It affects approximately 3.6 million people in France. Non-invasive ventilation (NIV) remains the reference treatment in hypercapnic respiratory failure because it reduces inspiratory muscles's work and promotes alveolar ventilation. The establishment of the NIV is carried out most of the time following an episode of acute decompensation revealing an underlying CRF. It is carried out and supervised in hospital departments to optimize the understanding and adherence of the patient to his illness and his treatment. Thus, monitoring is a key to measure the tolerance and effectiveness of ventilation. Classically, it is based on multi-year medical consultations, blood gases and nocturnal oximetry. In recent years, the reading of detailed data from software integrated into NIV machines has been increasingly used in current practice in association with the monitoring tools already recommended. It provides additional detailed information on compliance, leaks, apnea-hypopnea index (AHI), obstructive events and asynchrony between the patient and their ventilator. Many patient-ventilator asynchronies have been described in studies with a negative impact on the quality of ventilation, the quality of sleep under NIV and an increased risk of mortality. However, not all asynchronies have the same consequences and are not all felt by the patient ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05796297
Study type	Observational
Source	Nantes University Hospital
Contact	Sandrine JAFFRE, PH
Phone	33 2 40 16 52 51
Email	sandrine.jaffre@chu-nantes.fr
Status	Recruiting
Phase
Start date	June 1, 2023
Completion date	December 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05084976` - Parental Perception of COVID-19 Vaccine in Technology Dependent Patients
Not yet recruiting	`NCT05756387` - Improving Chronic Nocturnal Noninvasive Ventilation: a Multimodality Approach
Enrolling by invitation	`NCT04208581` - Yiqi Huoxue Huatan Granule for Reducing Mortality in COPD With Chronic Respiratory Failure	Phase 3
Recruiting	`NCT02260583` - Effect of Extracorporeal CO2 Removal in Stable Hypercapnic COPD Patients	N/A
Completed	`NCT01255111` - Adaptation to Nocturnal Noninvasive Ventilation in Patients With Chronic Respiratory Failure (ROOMILA)	N/A
Active, not recruiting	`NCT03499470` - Structured Discharge and Follow-up Protocol for COPD Patients Receiving LTOT and NIV	N/A
Completed	`NCT04143230` - Identification of In-hospital Patients in Need of Palliative Care Using a New Simplified Screening Tool	N/A
Terminated	`NCT00208078` - Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure.	Phase 4
Recruiting	`NCT06286917` - Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency	N/A
Completed	`NCT02342899` - Cost Effectiveness of Outpatient Set-up of Automated NIV in Obese Patients With Chronic Respiratory Failure	Phase 3
Terminated	`NCT03473171` - Implementation of Nasal Non-Invasive Ventilation With a RAM Cannula in the Inpatient /Outpatient Setting	N/A
Not yet recruiting	`NCT05258370` - Fibroblast Growth Factor 23 in Chronic Respiratory Failure
Completed	`NCT02804243` - The Efficacy of Nasal High Flow Oxygen Therapy With Rehabilitation in the Patients With Chronic Respiratory Failure	N/A
Completed	`NCT01479959` - Impact of Patient Controlled Positive End-expiratory Pressure on Speech in Tracheostomized Ventilated Patients	N/A
Completed	`NCT01090986` - Home Mechanical Ventilation Effectiveness and Air Leaks	N/A
Completed	`NCT00698958` - Ambulatory Adaptation to Non-Invasive Mechanical Ventilation	Phase 4
Not yet recruiting	`NCT06119087` - Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study	N/A
Recruiting	`NCT04481295` - Study on Optimal Oxygen Concentration During Pulmonary Rehabilitation	N/A
Withdrawn	`NCT05379439` - Family Connections	N/A
Terminated	`NCT03809832` - Microbiologic Contamination of Home Non Invasive Ventilators

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Clinical Impact of Patient-ventilator Asynchrony — INSPIRER

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms