Chronic Renal Disease Clinical Trial
Official title:
Identification of BIOmarkers for Detection and Understanding of Cardiovascular Complications in Chronic Kidney Disease
Identification of new retention solutes associated with cardiovascular (CV) toxicity in Chronic Kidney Disease (CKD) patients will help to better understand the pathophysiological mechanisms at stake and to prevent CKD-associated mortality and morbidity. For a molecule to be defined as a toxic retention solute, plasma accumulation in the course of CKD has to be demonstrated but also proof needs to be made that plasma accumulation during CKD is indeed associated with an increased risk of CV complications. Moreover, precise determination of the plasma concentration has to be performed in order to later study in vitro and in vivo the toxic mechanisms involved. Based on previous results of plasma proteome analysis using mass spectrometry, a previous study has selected 10 promising protein candidates. These proteins accumulated in the plasma of patients during CKD progression and are known to be associated with CV events in non-CKD patients. The objective of the present study is now to 1) evaluate the association of the plasma accumulation of the 10 retention solutes with CV complications in CKD patients and 2) determine their plasma concentration using ELISA. One hundred and seventy six patients with advanced CKD will be included and divided in 2 groups: 44 patients with history of CV complications in the past 4 years and 132 patients free of any CV complications.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT01155128 -
Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease
|
Phase 4 | |
| Completed |
NCT00962000 -
Study of How the Dose of Dialysis is Affected by Dialysate Flow Rate
|
N/A | |
| Completed |
NCT00560014 -
Nutrient Levels Alter Transplant Outcome
|
N/A | |
| Completed |
NCT01964014 -
Once-a-day Immunosuppression(CISECON_a_day)
|
Phase 4 | |
| Recruiting |
NCT01728415 -
Effects of High-intensity Interval Training in Patients in Hemodialysis
|
N/A | |
| Completed |
NCT01532297 -
Application of Citrate Dialysate in Chronic Haemodialysis
|
N/A | |
| Completed |
NCT04100551 -
Relationship Between Chronic Renal Disease and Risk Stratification for Chronic Ulcer on the on the Diabetic Foot
|
||
| Recruiting |
NCT04428827 -
Outcome of Patients With Primary Aldosteronism
|
||
| Completed |
NCT02299661 -
Pilot PK/PD Study of DS-1093a in Patients With Chronic Kidney Disease
|
Phase 1 | |
| Recruiting |
NCT02190318 -
Residual Renal Function Preservation in Peritoneal Dialysis Patients
|
N/A | |
| Terminated |
NCT01402219 -
Nephrotoxicity of Iopamidol Versus Iodixanol in High-Risk Patients
|
Phase 4 | |
| Not yet recruiting |
NCT04157647 -
Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response
|
N/A | |
| Completed |
NCT04897672 -
2D-speckle Tracking in Pediatric Renal Chronic Disease
|
||
| Terminated |
NCT02375711 -
Immunosenescence and Hepatitis B Virus (HBV) Vaccine Efficacy in Chronic Renal Disease Patient
|
N/A | |
| Not yet recruiting |
NCT04940819 -
A Mobile Application Based Dietary Self Management Intervention in Chinese Chronic Kidney Disease Patients
|
N/A | |
| Completed |
NCT01817322 -
Kidney Graft Function Under the Immunosuppression Strategies
|
Phase 4 | |
| Completed |
NCT05383261 -
The Impact of the Social Factors and Rehabilitation Program to Address the Implications on Kidney Failure in Hail
|
||
| Not yet recruiting |
NCT06439862 -
Study of the Quality of Life in School Aged-children With Posterior Urethral Valves
|
||
| Completed |
NCT02834026 -
Impact of the Cycle Ergometer in Muscle Strength and Pulmonary Function in Patients in Hemodialysis
|
N/A | |
| Completed |
NCT02072837 -
Dyslipidemia-related Risk Factors in Dialysis
|
N/A |