Residual Renal Function Preservation in Peritoneal Dialysis Patients

Status Recruiting

Clinical Trial Summary

Aldosterone blockade is useful in preserving residual renal function in patients on PD.The long term efficacy of dual blockade of the RAAS is better than monotherapy.

Clinical Trial Description

Residual renal function has been proven to contribute to improved survival and quality of life of dialysis patients. It is now recognized as an important factor in the prognosis of PD.The RAAS system is involved in the development of renal diseases. Angiotensin II and aldosterone are vital in this process. The beneficial effect of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker on residual renal function has been demonstrated in peritoneal dialysis patients. Unfortunately, neither ACE inhibition nor angiotensin receptor blocker fully supprsses aldosterone production. Now much focus has been placed on aldosterone antagonist. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02190318
Study type	Interventional
Source	Second Xiangya Hospital of Central South University
Contact	Hong Liu, MD,phD
Phone	86-0731-85292057
Email	liuh0618@163.com
Status	Recruiting
Phase	N/A
Start date	November 2013
Completion date	December 2015

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT01155128` - Effects of an Exercise Program in Patients With Hypertensive Chronic Kidney Disease	Phase 4
Completed	`NCT00962000` - Study of How the Dose of Dialysis is Affected by Dialysate Flow Rate	N/A
Completed	`NCT00560014` - Nutrient Levels Alter Transplant Outcome	N/A
Completed	`NCT03274921` - Biomarkers of Cardiovascular Complications in Chronic Kidney Disease
Completed	`NCT01964014` - Once-a-day Immunosuppression(CISECON_a_day)	Phase 4
Recruiting	`NCT01728415` - Effects of High-intensity Interval Training in Patients in Hemodialysis	N/A
Completed	`NCT01532297` - Application of Citrate Dialysate in Chronic Haemodialysis	N/A
Completed	`NCT04100551` - Relationship Between Chronic Renal Disease and Risk Stratification for Chronic Ulcer on the on the Diabetic Foot
Recruiting	`NCT04428827` - Outcome of Patients With Primary Aldosteronism
Completed	`NCT02299661` - Pilot PK/PD Study of DS-1093a in Patients With Chronic Kidney Disease	Phase 1
Terminated	`NCT01402219` - Nephrotoxicity of Iopamidol Versus Iodixanol in High-Risk Patients	Phase 4
Not yet recruiting	`NCT04157647` - Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response	N/A
Completed	`NCT04897672` - 2D-speckle Tracking in Pediatric Renal Chronic Disease
Terminated	`NCT02375711` - Immunosenescence and Hepatitis B Virus (HBV) Vaccine Efficacy in Chronic Renal Disease Patient	N/A
Not yet recruiting	`NCT04940819` - A Mobile Application Based Dietary Self Management Intervention in Chinese Chronic Kidney Disease Patients	N/A
Completed	`NCT01817322` - Kidney Graft Function Under the Immunosuppression Strategies	Phase 4
Completed	`NCT05383261` - The Impact of the Social Factors and Rehabilitation Program to Address the Implications on Kidney Failure in Hail
Completed	`NCT02834026` - Impact of the Cycle Ergometer in Muscle Strength and Pulmonary Function in Patients in Hemodialysis	N/A
Completed	`NCT02072837` - Dyslipidemia-related Risk Factors in Dialysis	N/A
Recruiting	`NCT03425708` - Effect of Hyperuricaemia on Chronic Renal Disease	Phase 4