Clinical Trials Logo

Clinical Trial Summary

A significant number of patients develop chronic post-surgical pain (CPSP) following knee replacement surgery. Proposed is the testing of a novel computer-assisted behavioral intervention integrating motivational interviewing in the 4 weeks prior to surgery to address the risk factors for CPSP, with the expectation that severity of post-op pain and the incidence of CPSP will be reduced.


Clinical Trial Description

A significant number of patients develop chronic post-surgical pain following knee joint replacement surgery, and the risk factors for this problematic outcome have been identified. Proposed is the development and preliminary efficacy testing of a novel computer-assisted cognitive behavioral intervention integrating motivational interviewing delivered in the four weeks prior to surgery to address these risk factors, with the expectation that both the severity of post-operative pain and the subsequent incidence of chronic post-surgical pain will be reduced. In that chronic post-surgical pain brings with it diminished functionality and quality of life, ongoing opioid use, and direct patient costs, it is critical that interventions aimed at mitigating its development are implemented and evaluated in the clinical setting. In a sample of adults over the age of 21 with chronic pain undergoing a planned TKA, the objectives of this randomized clinical trial are to: 1. Add a motivational interviewing component to a validated computer-assisted CBT intervention for chronic pain (painTRAINER) to encourage opioid tapering, if applicable, and program adherence in the 4 weeks prior to surgery in patients scheduled to undergo a TKA. 2. Describe the efficacy of the 4-week targeted pre-operative CBT intervention in 45 TKA patients to decrease preoperative chronic pain severity, preoperative opioid consumption, and symptoms of depression, anxiety and pain catastrophizing prior to surgery in comparison to 45 TKA patients randomized to treatment-as-usual. 3. Describe the effects of a 4-week targeted pre-operative CBT intervention in 45 TKA patients on 48hr post-operative pain severity, and 3- and 6-month rates of CPSP in comparison to 45 TKA patients randomized to treatment-as-usual. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04814992
Study type Interventional
Source University of Pennsylvania
Contact
Status Completed
Phase N/A
Start date October 1, 2020
Completion date December 31, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT05920382 - Radiofrequency Ablation for the Treatment of Post-knee Arthroplasty Chronic Pain. N/A
Completed NCT02240199 - Perioperative Pregabalin and Lidocaine to Reduce Chronic Breast Cancer Pain Phase 3
Recruiting NCT06382077 - Chronic Post Surgical Pain-Cardiac
Active, not recruiting NCT06392919 - The Impact of Repetitive Transcranial Magnetic Stimulation on the Prognosis of Elderly Surgical Patients N/A
Recruiting NCT03525938 - Transversus Abdominis Plane Block for Chronic Postsurgical Orchalgia N/A
Active, not recruiting NCT04681183 - Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain
Recruiting NCT05304286 - Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults N/A
Not yet recruiting NCT06344169 - Dinalbuphine Ester (Naldebain) for Pain Management After Cesarean Section Phase 2/Phase 3