Chronic Pain Due to Injury Clinical Trial
Official title:
Effects of Intramuscular Oxytocin on Pupil Diameter and Heart Rate Variability
The goal of this study is to test the effects of oxytocin on heart rate variability and pupil diameter, both of which have subtle effects on the activity rate of the autonomic nervous system.
This protocol focuses on two measures of autonomic control to quantify central actions of oxytocin. First, the study team proposes to examine the influence of oxytocin on heart rate variability with focus on its effect on high frequency variability, most commonly ascribed to parasympathetic nervous system activity acting to brake sympathetic tone. Intranasal oxytocin has been demonstrated to have a large effect size on this measure which can be repeated at frequent intervals. As a secondary assessment of parasympathetic activity, the study team will measure low frequency fluctuation in pupil diameter, termed hippus, which also reflects parasympathetic nervous system activity. This outcome measure can be assessed in 3 seconds using equipment currently being used under Institutional Review Board (IRB) approved protocols. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04822311 -
Evaluating the Impact of Focused Muscle Contraction Therapy in Retire APF Players
|
N/A | |
| Active, not recruiting |
NCT01967342 -
Literacy-Adapted Psychosocial Treatments for Chronic Pain --- "Learning About Mastering/My Pain"
|
N/A | |
| Completed |
NCT02560675 -
Why Does Acute Post Whiplash Injury Pain Transform Into Chronic Pain?
|
||
| Recruiting |
NCT03944447 -
Outcomes Mandate National Integration With Cannabis as Medicine
|
Phase 2 | |
| Completed |
NCT03119896 -
Supporting Self-management of Chronic Pain
|
N/A |