Effect of CPAP on Respiratory Load in COPD

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title: Effect of CPAP on Respiratory Load and Lung Volume in Stable COPD

Status Recruiting

Clinical Trial Summary

Both intrinsic positive end expiratory pressure (PEEPi) and dynamic hyperinflation are considered as inspiratory loads which increase work of breathing in patients with COPD. The application of extrinsic positive end expiratory pressure (PEEPe) supplied by CPAP has been claimed to reduce inspiratory load based on change in esophageal pressure which could be significantly affected by change in lung volume and airflow. The investigator hypothesized that CPAP could increase respiratory load because it increases lung volume.

Clinical Trial Description

Objective: To assess the effect of CPAP on respiratory load and lung volume in stable COPD. Methods: Patients with COPD were recruited to breath under the atmosphere pressure and different levels of CPAP (4, 6, 8 and 10 cm H2O). Diaphragm EMG, esophageal pressure (Pes) and transdiaphragmatic pressure (Pdi) were recorded using balloon esophageal electrode catheter (Yinghui, Guangzhou, China). End inspiratory lung volume (EILV) was measured directly from a pneumotachograph combined with a three way valve under the different CPAP levels. Sensation of breathing difficulty was also assessed. In an additional study, the effect of airflow on pressure was investigated by a physical mode. ;

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

• NCT number: NCT06390631
• Study type: Interventional
• Source: State Key Laboratory of Respiratory Disease
• Contact: Yuanming Luo, PHD
• Phone: +8613570033081
• Email: yluo15@bwh.harvard.edu
• Status: Recruiting
• Phase: N/A
• Start date: May 1, 2024
• Completion date: July 10, 2024