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A Study About Association Between Microbiome, Metabolome and Clinical Characteristics in COPD Patients

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
A Study About Association Between Microbiome, Metabolome and Clinical Characteristics in COPD Patients

Clinical Trial Summary

The goal of this observational registry study is to compare characteristics of gut and sputum microbiome and metabolome among COPD patients with significant smoking history, COPD patients without significant smoking history and healthy smoker. Additionally, the investigators investigate the difference of blood metabolites and peripheral blood mononuclear cells level among groups. The main questions it aims to answer are: - Are there significant difference in fecal or sputum microbiome and metabolome between COPD patients and healthy smoker? - Are there any distinct characteristics in microbiome and metabolome in COPD with COPD patients with significant smoking history, COPD patients without significant smoking history compared with healthy smoker? - Are there any difference in blood metabolites and peripheral blood mononuclear cells levels among patients with significant smoking history, COPD patients without significant smoking history and healthy smoker - Might distinct characteristics of microbiome and metabolites in COPD patients be related to worse clinical outcomes in COPD patients?

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06101459
Study type Observational [Patient Registry]
Source Asan Medical Center
Contact
Status Not yet recruiting
Phase
Start date December 1, 2023
Completion date December 31, 2028
View Details
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