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Pulmonary Diffusing Capacity During Acute Exercise in Patients With COPD — DiffLung2  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Pulmonary Diffusing Capacity to Nitric Oxide and Carbon Monoxide During Exercise in Patients With Chronic Obstructive Pulmonary Disease: a Test-retest Reliability Study

Clinical Trial Summary

The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) during exercise may be a useful physiological measure of alveolar-capillary reserve in patients with Chronic obstructive pulmonary disease (COPD). The present study investigated the test-retest reliability of DLCO/NO-based metrics.

Clinical Trial Description

The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. These changes are thought to involve acute changes in pulmonary perfusion and are notably relevant for patients with chronic obstructive pulmonary disease (COPD), in which they may be related to exertional dyspnoea. The aim of the present study is to investigate the effects of acute exercise on pulmonary diffusing capacity, and to determine the day-to-day repeatability of such assessments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05583396
Study type Interventional
Source Rigshospitalet, Denmark
Contact Ronan Berg, MD
Phone +45-35451825
Email ronan.martin.griffin.berg@regionh.dk
Status Recruiting
Phase N/A
Start date November 1, 2022
Completion date August 1, 2023
View Details
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