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Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease — CoStemCells  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Mapping and Characterization of Alveolar Cells During Smoking and Chronic Obstructive Disease

Clinical Trial Summary

To evaluate the regenerative capacities of mesenchymal cells composing the microenvironment of alveolar type 2 cells in a population of patients, undergoing thoracic surgery for suspected cancer, who are smokers with and without COPD compared to non-smokers patients

Clinical Trial Description

Chronic obstructive pulmonary diseases (COPD) have a major public health impact, as evidenced by the 250 million patients affected by these diseases and the 50% 5-year mortality for severe stages of chronic obstructive pulmonary disease (COPD). One pathophysiological mechanism of COPD and emphysema is a depletion of alveolar progenitor cells inducing a loss of alveolar-reparation capacities after an aggression. The genesis of these alterations and the mechanisms involved remain unknown. Alveolar type 2 cells (AT2) are the alveolar epithelial progenitor cells. AT2 proliferate and differentiate into alveolar type 1 cells (AT1) which form the alveolar-capillary barrier, along with endothelial cells, through which respiratory gas exchanges take place. The proliferation and differentiation of AT2 into AT1 are under the control of mesenchymal cells and endothelial cells located in close proximity. Together these cells form the alveolar stem cell niche. The characteristics and interactions of the different cell populations have been well described during lung growth, in the normal adult lung or during pulmonary fibrosis; however, participants are poorly described during smoking exposure and chronic obstructive diseases. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05227547
Study type Interventional
Source Centre Hospitalier Intercommunal Creteil
Contact JUNG Camille, MD
Phone 0145175000
Email camille.jung@chiccreteil.fr
Status Recruiting
Phase N/A
Start date October 5, 2022
Completion date October 5, 2030
View Details
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