Chronic Airway Disease, Mucus Rheology and Exacerbations — COPD-CARhE  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title: Chronic Airway Disease, Mucus Rheology and Exacerbations: a Randomized Controlled Trial of COPD Patients

Status Recruiting

Clinical Trial Summary

The main objective of this trial is to compare the exacerbation number over 12 months of follow-up between a group of patients with COPD treated according to standardized management (azithromycin prescribed in the event of severe sputum according to the CASA-Q score , standardized comparator arm) and a similar group in which azithromycin is prescribed based on mucus rheology (experimental arm) or CASA-Q.

Clinical Trial Description

The secondary objectives are to compare between the 2 arms:

• exacerbation number according to their severity (observed throughout the duration of the study);

• the evolution of the symptoms, the rheology of the sputum, and the pulmonary function (measurements repeated every three months);

• medication consumption and adverse events (monitored throughout the duration of the study);

• patient trajectories during follow-up;

• the overall clinical improvement at the end of the study and the evolution of the quality of life (measurements repeated every 3 months);

• the change in biomarkers of interest (baseline versus end of study). ;

Related Conditions & MeSH terms

• Chronic Obstructive Pulmonary Disease
• Lung Diseases, Obstructive
• Pulmonary Disease, Chronic Obstructive

• NCT number: NCT04339270
• Study type: Interventional
• Source: University Hospital, Montpellier
• Contact: Jérémy Charriot, MD
• Phone: 04 67 33 67 33
• Email: j-charriot@chu-montpellier.fr
• Status: Recruiting
• Phase: Phase 4
• Start date: February 3, 2023
• Completion date: February 2026