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Innovation in NOn Invasive Ventilation in COPD Patients Treated by Long Term Oxygen Therapy — INOV-LTOT  

Chronic Obstructive Pulmonary Disease Clinical Trial

Official title:
Non Invasive Ventilation and Nocturnal Alveolar Hypoventilation in Patients With Chronic Obstructive Pulmonary Disease (COPD) Treated by Long Term Oxygen Therapy at Home

Clinical Trial Summary

The aim of this study is to investigate the efficacy of non-invasive ventilation (NIV) on nocturnal hypoventilation in patients with chronic obstructive pulmonary disease (COPD) who are on long term oxygen therapy (LTOT) at home.

Clinical Trial Description

This is a prospective, randomized, open labelled study. The primary outcome is nocturnal transcutaneous CO2 (PtCO2) after 3 months of non-invasive ventilation. Three hundred COPD patients on LTOT will be screened and assessed by pulmonary function tests, blood gases and nocturnal PtCO2 at their home. This will allow the determination of the prevalence of nocturnal hypoventilation in COPD patients on LTOT (a secondary outcome) and to select patients who meet the inclusion criteria for the RCT and randomization to NIV + LTOT or to continue LTOT alone (n=38). Patients will undergo the same assessments at the end of the three-month intervention period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03584269
Study type Interventional
Source University Hospital, Grenoble
Contact
Status Terminated
Phase N/A
Start date June 28, 2018
Completion date September 23, 2019
View Details
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