Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease Complicated by Cor Pulmonale: A Pilot Study
Aim: To investigate whether patients with pulmonary hypertension have reduced absorption
capacity compared to COPD patients without cor pulmonale potentially due to venous
obstruction in the portal vein system.
The presence of cor pulmonale was determined by echocardiography. The concentration of
D-xylose and zinc were measured in peripheral blood one, two and three hours after ingestion
and used as markers of absorption. Furthermore, urine was collected for five hours to
determine the amount of excreted D-xylose.
Background: Cor pulmonale is a common complication to Chronic Obstructive Pulmonary Disease
(COPD), and may result in increased pressure in the inferior caval vein and stasis of the
liver. The chronic pulmonary hypertension may lead to stasis in the veins from the small
intestine and thereby compromise absorption of nutrients.
Aim: To investigate whether patients with pulmonary hypertension have reduced absorption
capacity compared to COPD patients without cor pulmonale.
Methods: Absorption of D-xylose (25 g) and zinc (132 mg), administered as a single dose, was
tested in 14 COPD patients, seven with and seven without cor pulmonale. The presence of cor
pulmonale was determined by echocardiography. The concentration of D-xylose and zinc were
measured in peripheral blood one, two and three hours after ingestion and used as markers of
absorption. Furthermore, urine was collected for five hours to determine the amount of
excreted D-xylose.
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