Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Impact of Resistance Training During Hospitalization in COPD Patients: a Randomized and Controlled Trial
The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).
Acute exacerbations are common in patients with COPD and cause specific signs and symptoms,
such as increased dyspnea, productive cough with altered sputum, and fever. With disease
progression, exacerbations are frequent and have a negative impact on health related quality
of life and pulmonary function as well as increase mortality. More severe exacerbations
require hospitalization resulting in enormous health expenditures, severely reducing daily
life activities and declining peripheral muscle strength that can be only partially reversed
after 3 months. Despite many features have been pointed out as responsible for the decrease
in muscle strength during hospitalization, physical inactivity seems the most important.
Resistance training is an interesting therapeutic option to prevent and/or reverse muscular
dysfunction due to immobilised in healthy subjects and stable COPD patients because induces
hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In
addition, provokes lower dyspnea perception during effort compared with other exercise
training. Despite these benefits for stable COPD, the impact of a resistance exercise
program during hospitalization remains poorly known.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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