Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
COPD patients have a reduced exercise tolerance due to a ventilatory limitation.
Several studies have shown altered skeletal muscle function. The investigator will study the
physiological response to knee-extensor exercise in COPD patients.
Reduced exercise tolerance is one of the hallmarks of COPD. The principal causes for
exercise intolerance are ventilatory limitation leading to deconditioning and inactivity.
However the weak correlation between exercise capacity and FEV1 implies that other factors
than reduced pulmonary function contribute to this impairment as well. Several studies have
found changes in skeletal muscle, with fibre shift, increased oxidative stress, increased
inflammatory cytokines and impaired mitochondrial function, suggesting a lower limb
dysfunction.
Numerous exercise studies in COPD patients have shown physiological and physiological
benefits of training and endurance training is now regarded as an important part in
pulmonary rehabilitation.
In this study we investigate training effects in patients with moderate to severe COPD with
special focus on skeletal muscle.
COPD patients will perform high intensity aerobic interval knee-extensor exercise training 3
days/week for six weeks . At baseline and follow-up, muscle oxygen consumption and
mitochondrial respiration will be measured.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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