Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Acute and Chronic Inflammatory Responses Induced by Smoking in Individuals Being Susceptible and Non-Susceptible for Development of COPD: From Specific Disease Phenotyping Towards Novel Therapy (Study 2).
COPD is ranked number 3 by the WHO list of important diseases worldwide and is the only
disease with increasing mortality. The pathogenesis of cigarette smoke-induced COPD is
obscure, therefore more insight is needed to design effective anti-inflammatory agents.
Recently it has become clear that cigarette smoke-induced inflammation is not only present
in the lungs but also in the blood, and that this systemic inflammation has important
consequences for the clinical expression of COPD. The investigators hypothesize that healthy
individuals who are susceptible to cigarette smoking demonstrate a higher and aberrant
systemic inflammatory response to cigarette smoke. This susceptibility is caused by
heterogeneous factors and is associated with various polymorphic genes that interact with
each other and with the environment.
Objective:
- To study systemic inflammation in individuals who are or are not susceptible to develop
COPD.
- To characterize the switch to chronicity of the systemic inflmmatory response in COPD
- To determine whether the type and severity of the systemic inflammation contributes to
the clinical outcome of COPD
- To compare between subjects who are or are not susceptible to develop COPD in
peripheral blood, the corticosteroid responsiveness in vitro, and to unravel underlying
mechanisms.
- To study the role of candidate genes that may play a role in the development of fixed
airway obstruction, and to identify clues for patient's responsiveness to specific
drugs
- To develop new biological and clinical markers for the early diagnosis and monitoring
of COPD
- To define possible mediators involved in the early induction of COPD in susceptible
smokers, and to define new drug targets
n/a
Observational Model: Case Control, Time Perspective: Prospective
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