Chronic Obstructive Pulmonary Disease Clinical Trial
Official title:
Randomized Trial,Comparative With Placebo, Double Blind, to Evaluate the Effect of the Treatment With 320 mg/d of Megestrol Acetate in Patients With Severe Chronic Obstructive Pulmonary Disease (COPD) and Loss of Body Weight. Pilot Study
The purpose of this trial is to study the effect of megestrol acetate in the gain of body weight in patients with severe Chronic obstructive pulmonary disease in order to improve the survival of the patients.
It has been demonstrated that the body weight measured as a Body mass index (BMI)is an
independent risk factor of mortality in the severe COPD.It seems to be one influence of
inflammatory factors in the development of denutrition in these patients.
The use of especial diets has no so good results in the aim to improve the weight, being
necessary to complement with muscular rehabilitation or anabolic products. The megestrol
acetate has demonstrated good results in a short period of time, nevertheless the studies
are scarce.
The beneficial effects of the megestrol acetate seems to be mediated by cytokines.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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