Chronic Obstructive Pulmonary Disease Clinical Trial
To test the effectiveness of a self-management program for chronic obstructive disease (COPD) patients. The program to improve adherence could be conducted by nurses or other clinic staff in settings where comprehensive rehabilitation services were not available.
BACKGROUND:
In 1990, the available data on medication adherence among chronic obstructive pulmonary
disease (COPD) patients consistently indicated that adherence was a significant problem.
This was a particularly distressing finding, considering that pharmacological therapy was
considered the backbone of COPD management in settings where comprehensive rehabilitation
services were limited. Despite the importance of this issue and a large data base on how to
enhance medication adherence among medical populations, there had been no empirical
investigations evaluating the implementation of these strategies with COPD patients.
DESIGN NARRATIVE:
The prospective, controlled study randomized 230 emphysema and chronic bronchitis patients
from an urban university medical center into either a "usual care", control group or into a
self-management skills training program for improving adherence. The training program was
based on self-management procedures for enhancing adherence which had proven efficacious
with diverse populations.
Self-reported and objective measures of adherence were examined during the two month
baseline period and the one year follow-up in the controlled study. A range of possible
covariates including demographics, patient characteristics, treatment, and therapeutic
outcome variables were also collected during the baseline phase and at the 6-month and
12-month follow-up visits in the controlled study to evaluate their relationship to the
observed adherence levels.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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