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Clinical Trial Summary

This study aims to analyze if patients with chronic obstructive lung disease who experience a decline of blood oxygen saturation during physical exercise have a disease course different from that of COPD patients who do not experience a decline in blood oxygen saturation during exercise. Patients will be followed for a total of 3 years.


Clinical Trial Description

The major aim of the study is to test whether intermittent hypoxaemia is a major driver of the progression of chronic obstructive lung disease (COPD). The second aim is to analyse whether dysregulation of the L-arginine / dimethylarginine pathway is a mechanistic link between intermittent hypoxemia and lung function decline, and whether plasma biomarkers are suitable to identify COPD patients at high risk of rapid lung function decline and mortality. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06265623
Study type Observational
Source Universitätsklinikum Hamburg-Eppendorf
Contact Rainer Böger, Prof. Dr.
Phone +49-40-7410
Email boeger@uke.de
Status Not yet recruiting
Phase
Start date March 1, 2024
Completion date September 30, 2029

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