Chronic Obstructive Pulmonary Disease (COPD) Clinical Trial
Official title:
Acetazolamide for Prevention of Altitude Related Illness in Patients With Chronic Obstructive Pulmonary Disease (COPD). Randomized, Placebo-Controlled, Double-Blind Trial.
Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing altitude related adverse health effects (ARAHE) in lowlanders with chronic obstructive lung disease travelling from 760 m to 3200 m.
This is a randomized, placebo-controlled, double-blind parallel trial evaluating the efficacy
of acetazolamide prophylaxis in reducing the incidence of altitude related adverse health
effects (ARAHE) in lowlanders with chronic obstructive pulmonary disease travelling to
altitude. Participants living in the Bishkek area, Kyrgyzstan (760m), will be transferred by
car within 4h to the Tuja Ashu high altitude clinic (3200 m), and stay there for 2 days.
Acetazolamide 375mg/day (or placebo), will be administered before departure at 760 m and
during the stay at altitude. Outcomes will be assessed during the stay at 3200 m.
An interim analysis will be carried out when 90 patients will have completed the study or
after the first year. The Peto's method will be used to correct the P-values.
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