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Clinical Trial Summary

The main objective is to assess the safety, tolerability, and efficacy of AMG 176 as monotherapy and in combination with the 7-day regimen of azacitidine for the treatment of Higher-Risk Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia (HR-MDS/CMML).


Clinical Trial Description

This study is a Phase 1 clinical trial designed to assess the safety, tolerability, and efficacy of AMG 176 as monotherapy and in combination with the 7-day regimen of azacitidine for the treatment of HR-MDS/CMML. Participants will be treated with intravenous (IV) AMG 176 and IV or subcutaneous (SC) azacitidine. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05209152
Study type Interventional
Source Amgen
Contact Amgen Call Center
Phone 866-572-6436
Email [email protected]
Status Not yet recruiting
Phase Phase 1
Start date November 7, 2022
Completion date December 1, 2025

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