Chronic Myeloid Leukemia or Ph Positive ALL Clinical Trial
Official title:
Patterns of ABL Mutation in Asian With Imatinib Resistant Chronic Myeloid Leukemia and Ph Positive Acute Lymphocytc Leuekmia Patients (AMICA): A Retrospective Feasibility Study
The purposes of this study are to investigate the patterns of BCR-ABL mutations in CML and Ph positive ALL patients with imatinib resistance during the year of 2001-2009 in Asian institutes.
Awareness of the significance of BCR-ABL mutations is generally low across Asia. This is
partly due to historical limitations in capabilities for mutation testing. While numerous
mutation studies have been done in non-Asian populations, there are very few published
reports on mutations in Asians. CML management in Asia therefore continues to be largely
intuitive.
Anecdotal reports, suggest that there may differences in the presence or absence of
mutations at the time of initial diagnosis and their occurrence during imatinib treatment.
At present, however, we have no comprehensive formal knowledge of the actual nature of
mutations in Asians. There are moves towards the establishment of CML registries that will
capture the pattern of mutations among Asian patients.
In recent years, several laboratories in the region have been performing mutation analysis.
However, no systematic evaluation of or report on these data has been undertaken. This study
therefore intends to collect documented mutation data in Asian CML and Ph positive ALL
patients from identified Asian institutes. While this is a retrospective, cross-sectional
analysis of mutation information, the study will provide the first comprehensive formal
report on mutations in Asian CML and Ph positive ALL patients. The collecting information
has the potential better to inform the clinical management of CML and Ph positive ALL in
Asia according to the mutation result and possibly future research in these patients.
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Observational Model: Cohort, Time Perspective: Retrospective