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Clinical Trial Summary

The purpose of this study is to determine if adding Ruxolitinib to a Tyrone Kinase Inhibitor (TKI), prior to a second attempt at stopping a TKI will lead to prolonged treatment free remission (TFR).


Clinical Trial Description

All participants will have a confirmed diagnosis of chronic phase chronic myeloid leukemia (CML) and must have previously attempted to discontinue TKI therapy. All participants must be restarted on a TKI at the time of relapse in order to be eligible for this trial. After completion of 12 cycles of combination therapy, eligible participants will remain in the TFR phase of the study for up to 36 months, and will have central polymerase chain reaction (PCR) testing during the first 24 months. Therefore, the total duration of the trial will be approximately 48 months (12 months on combination treatment phase + 36 months in the TFR phase). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03610971
Study type Interventional
Source H. Lee Moffitt Cancer Center and Research Institute
Contact
Status Recruiting
Phase Phase 2
Start date November 19, 2019
Completion date January 2025

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