Chronic Lymphocytic Leukemia Clinical Trial
Official title:
Polymorphism of the ITGA4 Gene (Integrin Subunit Alpha 4) in Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder that is characterized by heterogeneous presentation at the clinical and molecular levels. ITGA4 protein has been found to be deregulated in CLL with adverse clinical outcome. ITGA4 gene (CD49d) encodes a member of the integrin alpha chain family of proteins and is considered a negative prognosticator in CLL with aggressive course and short time to treatment. The aim of the study: is to investigate ITGA4 gene expression pattern in CLL.
| Status | Not yet recruiting |
| Enrollment | 80 |
| Est. completion date | October 1, 2024 |
| Est. primary completion date | August 1, 2024 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | N/A and older |
| Eligibility | Inclusion Criteria: - Patients with newly diagnosed CLL. Exclusion Criteria: - ? Patients previously diagnosed as CLL and received treatment before. - Patients with other solid tumors. |
| Country | Name | City | State |
|---|---|---|---|
| Egypt | Sohag university | Sohag |
| Lead Sponsor | Collaborator |
|---|---|
| Sohag University |
Egypt,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | ITGA4 gene expression pattern in chronic lymphocytic leukemia | Detection of ITGA4 gene expression in blood samples in patients with chronic lymphocytic leukemia, Briefly, total RNA and genomic DNA extraction from fresh peripheral blood samples by Real-time -RT-polymerase chain reaction system (RT-PCR) will be carried out. Rate of ITGA4 gene expression will be recorded. | 1 year following the startpoint of the study |
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