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NCT05371392 Clinical Trial

ITGA4 Gene Methylation Status in Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia Clinical Trial

Official title:
ITGA4 Gene Methylation Status in Chronic Lymphocytic Leukemia

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05371392
Other study ID # soh-med-22-04-21
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date July 1, 2022
Est. completion date October 1, 2023

Study information
Verified date May 2022
Source Sohag University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disorder that is characterized by heterogeneous presentation at the clinical and molecular levels. ITGA4 protein has been found to be deregulated in CLL with adverse clinical outcome. ITGA4 gene (CD49d) encodes a member of the integrin alpha chain family of proteins and is considered a negative prognosticator in CLL with aggressive course and short time to treatment. The aim of the study: is to investigate ITGA4 gene expression pattern and to explore its methylation heterogeneity in CLL.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 80
Est. completion date October 1, 2023
Est. primary completion date August 1, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - Patients with newly diagnosed CLL. Exclusion Criteria: - ? Patients previously diagnosed as CLL and received treatment before. - Patients with other solid tumors.

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Sohag University

Outcome
Type Measure Description Time frame Safety issue
Primary ITGA4 gene expression pattern and its methylation heterogeneity in chronic lymphocytic leukemia Detection of ITGA4 gene expression and ITGA4 gene methylation in blood samples in patients with chronic lymphocytic leukemia, Briefly, total RNA and genomic DNA extraction from fresh peripheral blood samples by Real-time -RT-polymerase chain reaction system (RT-PCR) will be carried out. Rate of ITGA4 gene expression and its methylation will be recorded. 1 year following the startpoint of the study
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