Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

Chronic Knee Pain Clinical Trial

Official title: Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study

Status Recruiting

Clinical Trial Summary

To compare the effects of the following types of therapy on knee range of motion when given to patients with chronic knee pain:

• A standard steroid injection

• Peripheral nerve stimulation (PNS) therapy in combination with a standard steroid injection

• PNS therapy in combination with a placebo injection

Steroid injections are given directly into the knee joints and are considered to be the standard therapy for chronic knee pain. In this study, the injection will be made of the steroid drugs triamcinolone and bupivacaine.

Clinical Trial Description

Primary Objectives:

• To compare the mean change in knee range of motion using goniometry from at 30 days (visit 2) from baseline among the three treatment arms.

Secondary Objectives:

• To compare the mean change in knee range of motion using goniometry at 60 days (visit 3) and 90 days (visit 4) from baseline among the three treatment arms.

• To compare changes in knee pain scores (NRS), WOMAC index, use of opioids (measured in morphine milliequivalent), and incidence of complications and adverse effects at 30 days, 60 days, and 90 days from baseline among the three treatment arms ;

Related Conditions & MeSH terms

• Chronic Knee Pain

• NCT number: NCT06004882
• Study type: Interventional
• Source: M.D. Anderson Cancer Center
• Contact: Saba Javed, MD
• Phone: (713) 792-9530
• Email: sjaved@mdanderson.org
• Status: Recruiting
• Phase: N/A
• Start date: August 10, 2023
• Completion date: January 31, 2026