Chronic Knee Osteoarthritis Clinical Trial
Official title:
Combined Ultrasound Guided Genicular Nerve and Intra-articular Pulsed Radiofrequency Versus Intra-articular Platelet Rich Plasma Injection for Chronic Knee Osteoarthritis; A Comparative Study
The social impact of degenerative diseases such as articular cartilage pathology and
osteoarthritis (OA) is steadily increasing, because of the continued rise in the mean age of
the active population. A variety of noninvasive solutions have been proposed for pain
treatment, improvement in function and disability, and ultimately, modification of the course
of severe cartilage lesions and OA, with variable success rates. Intra articular and
genicular nerves radiofrequency (RF) is a minimally invasive technique that usually aims at
the neuropathic pain. One important mechanism for the chronic pain mediated by OA is
peripheral sensitization, which increases the transmission of pain signals. Through
conduction block in pain-transmitting nerve fibers by thermal damage, RF could ease pain
without destroying the antennal nerve. The role of growth factors (GFs) in chondral repair is
now widely investigated in vitro and in vivo.
Platelet-rich plasma (PRP) is a simple, low cost, and minimally invasive method that allows
one to obtain from the blood a natural concentrate of autologous GFs.
The aim of this study is to compare the efficacy of intra articular Platelet Rich Plasma
(PRP) injection versus combined ultrasound guided intra articular and genicular nerve pulsed
radiofrequency on chronic knee pain in patients with knee osteoarthritis.
The regeneration capacity of cartilage is limited because of its isolation from systemic
regulation and its lack of vessels and nerve supply. Osteoarthritis (OA) has a major impact
on functioning and independence and ranks among the top 10 causes of disability worldwide
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04112264 -
Ultrasound-guided Monopolar Versus Bipolar Radiofrequency Ablation for Genicular Nerves in Chronic Knee Osteoarthritis
|
N/A | |
| Recruiting |
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Ultrasound-guided Radiofrequency Ablation of the Genicular Nerve Versus Physical Therapy for Chronic Knee Osteoarthritis
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