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Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)

Chronic Kidney Diseases Clinical Trial

Official title:
Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)

Clinical Trial Summary

Phase 1 basket trial including 2 open-label single-arm cohorts: REPAIR CKD cohort and REPAIR Dialysis cohort. Open label colchicine 0.3 mg daily for 8 weeks followed, in patients who tolerated the 0.3 mg dose, by forced titration to 0.6 mg daily for 8 weeks.

Clinical Trial Description

The REPAIR CKD cohort will enroll 100 patients with chronic kidney disease not requiring dialysis. The REPAIR Dialysis cohort will enroll 100 patients with chronic kidney disease requiring chronic maintenance dialysis. Each participant will be followed for up to 17 weeks, to determine among adults with severe chronic kidney disease not requiring dialysis and (separately) in those requiring dialysis, the proportion who, over 8 weeks of treatment, discontinue colchicine 1) 0.3 mg daily and 2) 0.6 mg daily. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06203977
Study type Interventional
Source Hamilton Health Sciences Corporation
Contact Courtney Christou, BSc
Phone 905-521-2100
Email courtney.christou@phri.ca; repair@phri.ca
Status Not yet recruiting
Phase Phase 1
Start date May 1, 2024
Completion date December 31, 2025
View Details
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