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NCT06006819 Clinical Trial

Prognostic Markers of Acute Heart Failure With Chronic Kidney Disease

Chronic Kidney Diseases Clinical Trial

Official title:
Plasma Proteomic Signature and the Prognosis of Acute Heart Failure With or Without Chronic Kidney Disease

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06006819
Other study ID # CHGH(983)111A-61
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 1, 2023
Est. completion date December 23, 2025

Study information
Verified date August 2023
Source Cheng-Hsin General Hospital
Contact Shang Feng Yang, MD
Phone +886-22826-4400
Email samyang1223@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute heart failure (AHF) is defined as new or worsening of symptoms and signs of heart failure and is the most frequent cause of unplanned hospital admission in elderly patients. N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is one of the most developed prognostic markers for AHR patients and. NT-pro-BNP has limitations in terms of diagnostic or predictive accuracy in patients with chronic kidney disease (CKD). Plasma proteomics have the potential to examine underlying pathophysiological and prognostic roles, so we compared the plasma proteomic signature to predict outcomes of patients with or without CKD hospitalized for AHF.

Recruitment information / eligibility
Status Recruiting
Enrollment 155
Est. completion date December 23, 2025
Est. primary completion date December 23, 2025
Accepts healthy volunteers No
Gender All
Age group 20 Years to 90 Years
Eligibility Inclusion Criteria: - hospitalized for acute heart failure Exclusion Criteria: - initial serum NT-proBNP level <300ng/ml, pregnancy, amputated, and end-stage renal disease under regular dialysis

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan Cheng Hsin General Hospital Taipei Baitou District

Sponsors (1)
Lead Sponsor Collaborator
Cheng-Hsin General Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome
Type Measure Description Time frame Safety issue
Primary major adverse cardiovascular events mortality, acute myocardial infarction, acute stroke, and heart failure hospitalization 1 year
Secondary major adverse kidney events mortality, new end-stage renal disease, and 30% decline in estimated GFR 1 year
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